|
Symbol Name ID |
Brca2
breast cancer 2, early onset MGI:109337 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hypogonadism |
Hypospadias |
Abnormal preputium morphology |
Abnormal testis morphology |
Absent testis |
Cryptorchidism |
Prostate cancer |
Dysgerminoma |
Ovarian carcinoma |
Ovarian papillary adenocarcinoma |
Abnormality of the uterus |
Endometrial carcinoma |
Bicornuate uterus |
Azoospermia |
Decreased fertility in males |
| Disease(s) Associated with BRCA2 | |||||||||||||||
| endometrial cancer | |||||||||||||||
| Fanconi anemia | |||||||||||||||
| ovarian cancer | |||||||||||||||
| pancreatic cancer | |||||||||||||||
| prostate cancer |
| Mouse Phenotypes | reproductive system phenotype |
azoospermia |
absent germ cells |
prostate gland hyperplasia |
absent ovarian follicles |
small ovary |
ovary degeneration |
small testis |
increased prostate intraepithelial neoplasia incidence |
abnormal prostate gland physiology |
female infertility |
male infertility |
|
| Availability | Mouse Genotype | ||||||||||||
| Brca2tm1.1Sks/Brca2tm1.1Sks | * | ||||||||||||
| Brca2tm1Cam/Brca2tm1Cam | |||||||||||||
| Brca2tm1Cbl/Brca2tm1Cbl | |||||||||||||
| Brca2tm1Kamc/Brca2tm1Kamc | * | ||||||||||||
| Brca2tm2.1Sks/Brca2tm2.1Sks | * | ||||||||||||
| Brca2tm1Brd/Brca2tm1.1Sks | * | ||||||||||||
| Brca2tm1Mbn/Brca2+ | * | ||||||||||||
| Brca2tm2.1Sks/Brca2tm1Brd | * | ||||||||||||
| Brca2tm1Brn/Brca2tm1Brn Tg(Pbsn-cre)4Prb/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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